kerafast總代理(li)靶(ba)點科技貨號EB0011單克隆抗體Anti-VSV-M [23H12] Antibody與VSV-M蛋白反應。

產品特色：

-與VSV-M蛋白發生反(fan)應(ying)

-適用(yong)于蛋白(bai)質印跡應用(yong)

背(bei)景介紹：

水(shui)皰性口(kou)炎病毒（VSV）是一種經過充分(fen)研究的(de)(de)包膜負(fu)鏈RNA病毒。VSV 基(ji)因組編碼(ma) 5 種蛋(dan)白質：N、P、M、G 和(he) L。G蛋(dan)白（糖蛋(dan)白）位(wei)于(yu)病毒粒(li)子表(biao)面，負(fu)責病毒附著(zhu)和(he)滲透。此外，許多慢靜脈載體是用(yong)來(lai)自(zi)印第安(an)納州血清型的(de)(de)VSV-G假分(fen)型的(de)(de)。

水皰(pao)性(xing)口炎(yan)病(bing)(bing)毒(du)（VSV）是一種(zhong)經過充分研究的(de)包膜(mo)負(fu)(fu)鏈(lian)RNA病(bing)(bing)毒(du)。VSV 基(ji)(ji)因組(zu)編碼 5 種(zhong)蛋(dan)(dan)(dan)白(bai)質：N、P、M、G 和 L。M蛋(dan)(dan)(dan)白(bai)（或(huo)基(ji)(ji)質蛋(dan)(dan)(dan)白(bai)）負(fu)(fu)責(ze)結(jie)合(he)核衣(yi)殼并將其(qi)凝聚(ju)成緊密盤繞的(de)螺旋，并將核衣(yi)殼與包膜(mo)結(jie)合(he)。M蛋(dan)(dan)(dan)白(bai)的(de)這(zhe)種(zhong)活性(xing)使病(bing)(bing)毒(du)具有彈狀的(de)形狀。除了M蛋(dan)(dan)(dan)白(bai)在病(bing)(bing)毒(du)組(zu)裝中(zhong)的(de)作用外，它還負(fu)(fu)責(ze)介導VSV發病(bing)(bing)機(ji)制(zhi)的(de)分子(zi)機(ji)制(zhi)。野生(sheng)M型蛋(dan)(dan)(dan)白(bai)抑制(zhi)感(gan)染細胞中(zhong)的(de)宿主(zhu)基(ji)(ji)因表達并抑制(zhi)抗病(bing)(bing)毒(du)反應。

Background：

Vesicular stomatitis virus (VSV) is a well studied, enveloped, negative-strand RNA virus. The VSV genome encodes for 5 proteins: N, P, M, G, and L. The G protein (glycoprotein) is located at the virion surface and is responsible for virus attachment and penetration. Additionally, many lentivrial vectors are pseudotyped with VSV-G from the Indiana serotype.

Vesicular stomatitis virus (VSV) is a well studied, enveloped, negative-strand RNA virus. The VSV genome encodes for 5 proteins: N, P, M, G, and L. The M protein (or matrix protein) is responsible for binding the nucleocapsid and condenses it into a tightly coiled helix and binds the nucleocapsid to the envelope. This activity of the M protein is what gives the virus its bullet like shape. In addition to M protein's role in virus assembly, it is also responsible for mediating molecular mechanisms of VSV pathogenesis. Wild-type M protein surpresses host gene expression in infected cells and inhibits antiviral responses.

產品詳情：